model

Passage Bio’s PBGM01 shows encouraging pre-clinical benefits in murine model of GM1 gangliosidosis (NASDAQ:PASG)

Passage Bio (NASDAQ:PASG) announces publication of data in a murine model of GM1 gangliosidosis (GM1) demonstrating that a single intracerebroventricular injection of an optimized adeno-associated virus (PBGM01) into the cerebral spinal fluid (CSF) resulted in significant expression of Beta-galactosidase (β-gal) in the brain and peripheral tissues, and demonstrated dose-related reductions in neuronal lysosomal storage lesions, neurological impairment and improvement in survival.

GM1 is a rare and often life-threatening lysosomal storage disease caused by mutations in the GLB1 gene, which encodes lysosomal acid β-gal.

The mice received the single administration at age one month and were evaluated over 300 days. β-gal activity was increased significantly in the CSF and serum of the vector-treated mice compared to vehicle control-treated mice.

Considerable improvements in gait assessments and preservation of neurological function were observed throughout the study period.

There were significant decreases in lysosomal storage lesions of vector-treated animals, and by day 300, all

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beauty

These beauty brands are encouraging people to vote

Many beauty labels are encouraging their customers to vote with limited-edition products and merchandise. Other big-name beauty brands are giving their employees time off to vote or volunteer as poll workers on November 3.

Former First Lady Michelle Obama teamed up with The Lip Bar for a limited-edition red lipstick. There were only 500 units of the exclusive matte liquid shade called “Bawse Voter” (which have all sold out). Forty percent of the proceeds are donated to When We All Vote, the nonpartisan organization that promotes voter turnout.

Lip bar founder Melissa Butler appeared on ABC’s “Shark Tank” TV series as a contestant for the beauty brand, which sells vegan and cruelty-free makeup. “Our goal is to make your makeup routine as easy as possible so you can spend time on the things that matter most to you — and right now, for many of us, that’s politics,” she said.

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coupon

Smoothie King Encouraging Healthier Lifestyles with its Fast-Food Coupon Swap

DALLAS, Oct. 6, 2020 /PRNewswire/ — Smoothie King is encouraging better meal choices with a Fast-Food Coupon Swap. From October 6 – 15, present any digital or physical coupon from another quick-service restaurant at checkout, and Smoothie King will knock $2 off your smoothie.

“Now more than ever, people are opting for on-the-go meals they can get safely and conveniently, but those meals may not be the healthiest and other smoothies out there have a bunch of added sugar,” said Smoothie King CMO Rebecca Miller. “With this coupon swap, we’re actively encouraging guests to make better-for-you decisions with a wide variety of smoothies made with whole fruits and veggies while also saving them money. It’s a win-win.”

With this promotion running for 10 days, guests have multiple opportunities to receive a discount on all regular-sized smoothies, including the new Vegan Mixed Berry. This plant-based meal smoothie is made with

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