New 3-D model of a DNA-regulating complex in human cells provides cancer clues — ScienceDaily

Scientists have created an unprecedented 3-dimensional structural model of a key molecular “machine” known as the BAF complex, which modifies DNA architecture and is frequently mutated in cancer and some other diseases. The researchers, led by Cigall Kadoch, PhD, of Dana-Farber Cancer Institute, have reported the first 3-D structural “picture” of BAF complexes purified directly from human cells in their native states — rather than artificially synthesized in the laboratory -providing an opportunity to spatially map thousands of cancer-associated mutations to specific locations within the complex.

“A 3-D structural model, or ‘picture,’ of how this complex actually looks inside the nucleus of our cells has remained elusive — until now,” says Kadoch. The newly obtained model represents “the most complete picture of the human BAF complex achieved to date,” said the investigators, reporting in the journal Cell.

These new findings “provide a critical foundation for understanding human disease-associated mutations

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Megan Thee Stallion Speaks Up For Black Women in Powerful Essay: ‘We Deserve to Be Protected as Human Beings’

“We were not in a relationship. Truthfully, I was shocked that I ended up in that place. My initial silence about what happened was out of fear for myself and my friends. Even as a victim, I have been met with skepticism and judgment. The way people have publicly questioned and debated whether I played a role in my own violent assault proves that my fears about discussing what happened were, unfortunately, warranted.”

The rapper notes that in the weeks leading up to the Nov. 3 election Black women are “expected to once again deliver victory for Democratic candidates,” noting that Black women have gone from being unable to vote legally to being a “highly courted” voting bloc in just over a century. “Despite this and despite the way so many have embraced messages about racial justice this year, Black women are still constantly disrespected and disregarded in so many

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The Case For A More Human Leadership Model

Bruno Guicardi is President of CI&T, the digital solutions partner driving lean digital transformation for the world’s biggest brands.

Best-selling author Gary Hamel recently shared some stats that represent a startling reality: “Only one in five employees believe their opinions matter at work … and one in 11 say they can influence important decisions.”

Much has been said about employee empowerment and a work environment that’s more inclusive, but the discussion tends to center on talent attraction and retention as if this was only an HR issue. My provocation in this article is that we should look at empowerment in the workplace as our best bet to tackle the ever-increasing unpredictability in the business environment and to thrive as a business.

The 20th-century formula to solving problems in which companies analyzed the situation, broke it down and came up with a detailed plan doesn’t work anymore. In the

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Women’s health care is a human right. It’s why I’m supporting Biden-Harris

Genevieve Leo, Opinion contributor
Published 7:00 a.m. MT Oct. 9, 2020


Opinion: The Trump administration has made it harder to access no-cost birth control for women and girls and allowed for discrimination in health care. We can reverse this.

It is an isolating feeling, receiving abnormal test results after an annual OBGYN visit (I’m fine). It’s even more terrifying to absorb this information just a month before a close relative was diagnosed with ovarian cancer.

My fear caused overwhelming anxiety.

Going to the doctor is scary and uncomfortable, especially when we don’t know or understand what to expect, what is considered “normal” or “irregular.” But it does not have to be this way. Having a mother as an OBGYN who was able to talk me through basic women’s health information was essential for my understanding and well-being.

Imagine if

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GOP report claims Hunter Biden paid women linked to ‘prostitution or human trafficking ring’

Among the deluge of explosive claims tucked inside the new Senate Republican report about Hunter Biden’s business dealings is the allegation that the Democratic presidential nominee’s son has a history of paying Russian or Eastern European women linked to sex trafficking.

While the 87-page report, which was released on Wednesday, provided few specific details regarding the allegation, it pointed to a number of Russian- and Ukrainian-connected transactions.

“Hunter Biden paid nonresident women who were nationals of Russia or other Eastern European countries and who appear to be linked to an ‘Eastern European prostitution or human trafficking ring,’” read the report from the Homeland Security and Governmental Affairs and Finance Committees.


The GOP report did not link Biden in any way to trafficking but suggested that he potentially paid prostitutes, presumably without knowledge, who may have stemmed from such rings.

“There is

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