model

Researchers create p16-Cre ERT2 -tdTomato mouse model to characterize in vivo senescent cells

Cell senescence is a state of permanent cell cycle arrest that was initially defined for cells grown in cell culture. It plays a key role in age-associated organ dysfunction and age-related diseases such as cancer, but the in vivo pathogenesis is largely unclear.

A research team led by Professor Makoto Nakanishi of the Institute of Medical Science, the University of Tokyo, generated a p16-Cre ERT2 -tdTomato mouse model to characterize in vivo p16 high cells at the single-cell level.

They found tdTomato-positive p16 high cells detectable in all organs, which were enriched with age. They also found that these cells failed to proliferate and had half-lives ranging from 2.6 to 4.2 months, depending on the tissue examined.

Single-cell transcriptomics in the liver and kidneys revealed that p16 high cells were present in various cell types, though most dominant in hepatic endothelium and

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accesories

Microsoft announces new keyboard, mouse and other accessories

As people around the world are settling into new work- or study-from-home routines, Microsoft is rolling out new products it says will upgrade your home office space. The tech giant has announced accessories to accompany its new Surface products, including a compact keyboard and mouse.

Microsoft describes the new Designer Compact Keyboard as “slim, narrow and elegant.” The keyboard has a two-year battery life, and thanks to Bluetooth capability can switch between three devices. It starts at $69.99. For those who don’t need a full keyboard (or want to add more features to the Compact Keyboard), Microsoft is offering a similarly small and wireless number pad for $24.99.

If you’re looking to make your home office experience comfortable and conducive to long hours in front of the computer, Microsoft has designed a “light and durable” Bluetooth Ergonomic Mouse with a soft thumb rest. The wireless mouse is priced at $49.99.

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