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3D structural model of BAF complex modifies DNA architecture, provides clues on cancer

Scientists have created an unprecedented 3-dimensional structural model of a key molecular “machine” known as the BAF complex, which modifies DNA architecture and is frequently mutated in cancer and some other diseases.

The researchers, led by Cigall Kadoch, PhD, of Dana-Farber Cancer Institute, have reported the first 3-D structural “picture” of BAF complexes purified directly from human cells in their native states – rather than artificially synthesized in the laboratory -providing an opportunity to spatially map thousands of cancer-associated mutations to specific locations within the complex.

“A 3-D structural model, or ‘picture,’ of how this complex actually looks inside the nucleus of our cells has remained elusive – until now,” says Kadoch. The newly obtained model represents “the most complete picture of the human BAF complex achieved to date,” said the investigators, reporting in the journal Cell.

These new findings “provide

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Elon Musk confirms Tesla’s new structural battery and cells are first going to Model Y at Giga Berlin

Elon Musk has confirmed Tesla’s new structural battery design, and 4680 cells are first going to Model Y, which will be produced at Gigafactory Berlin next year.

We already had a good idea it was happening since Musk teased that Tesla will introduce a “core structural design change” with Model Y produced in Germany, but it’s not confirmed.

The CEO confirmed on Twitter that the new structural battery pack technology will be first implemented in Berlin:

Berlin will use 4680 cell with structural battery pack and front & rear single-piece castings. Also, a new paint system.

Tesla plans to first start Model Y production at Gigafactory Berlin during the second half of 2021.

Musk added that he believes it will take about two years:

Lot of new technology will happen in Berlin, which means significant production risk. Fremont & Shanghai will transition in ~2 years when new tech is proven.

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